Exploring the role of cellular plasticity in metabolic dysfunction-associated steatosis and related molecular mechanisms
Long-term high insulin stimulation is driving dedifferentiation of hepatocytes and causes the formation of fibroadipogenic progenitor cells. Long-term exposure of these cells to high fatty acids leads to adipogenesis, mainly via TLR4/GSK3β and fibrogenesis, via TLR4/β-catenin pathways.
Authors
- Merve Erçin (ORCID: https://orcid.org/0000-0001-7755-0762)
- Selda Gezginci-Oktayoğlu (ORCID: https://orcid.org/0000-0002-1378-1585)
Institutions
- Istanbul University (TR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12967-025-06922-4
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00