Succinate-driven virulence enhancement in hypervirulent <i>Klebsiella pneumoniae</i> via DcuSR two-component system
Succinate, a C<sub>4</sub>-DC, is produced by the host and the gut microbiota and can accumulate in the intestinal environment under various pathological conditions, such as diabetes and inflammatory bowel disease. It acts as a pivotal regulator of virulence traits and metabolic pathways in Enterobacteriaceae. Our findings highlight the significant impact of succinate on hvKP pathogenesis: (i) functioning through the DcuSR TCS to activate virulence programs and (ii) serving as a metabolic substrate that fuels bioenergetic adaptation through ATP synthesis.
Authors
- Cong Shen (ORCID: https://orcid.org/0000-0003-2677-3960)
- Mingyong Luo (ORCID: https://orcid.org/0000-0002-1202-1429)
- Huanliang Liu (ORCID: https://orcid.org/0000-0002-1006-6666)
- Ruru Deng (ORCID: https://orcid.org/0000-0002-4560-2000)
- Jianming Zeng (ORCID: https://orcid.org/0000-0002-7020-3386)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-8585-0922)
- Bin Huang (ORCID: https://orcid.org/0000-0001-8769-7979)
- Shibing Li (ORCID: https://orcid.org/0009-0006-7000-2572)
- Siyu Zhao (ORCID: https://orcid.org/0000-0003-3754-4354)
- Jieying Pu (ORCID: https://orcid.org/0000-0002-7473-6972)
- Chen Cha (ORCID: https://orcid.org/0000-0001-7275-1231)
- Guosheng Zhong (ORCID: https://orcid.org/0009-0004-7124-5387)
- Xiaoya Yang (ORCID: https://orcid.org/0009-0002-2727-6544)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Women's and Children's Hospital (AU)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Province Women and Children Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1128/spectrum.01453-25
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00