Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study
This study provides a comprehensive analysis of glutamine metabolism in BLCA and introduces a clinically relevant prognostic model. PYCR1 was identified as a central metabolic regulator, underscoring its critical role in tumor development and progression.
Authors
- Xinjia Ding
- Shikai Wu (ORCID: https://orcid.org/0000-0002-0317-3148)
- Enkui Zhang
- Xiaohui Li (ORCID: https://orcid.org/0000-0001-9653-9227)
- Chao Liu (ORCID: https://orcid.org/0000-0003-3863-7210)
- Zhigao Wang (ORCID: https://orcid.org/0000-0003-1821-4843)
- Zhou Huang (ORCID: https://orcid.org/0000-0001-9385-0597)
- Yanping Wu (ORCID: https://orcid.org/0000-0001-8455-3574)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12967-025-07386-2
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China