Non-inferiority of Rituximab versus OCrelizumab in Multiple Sclerosis (ROC-MS)—an individual participant data meta-analysis
This ROC-MS collaboration will improve the precision of the estimates, increase statistical power for outcomes and assessment of rare events and facilitate subgroup analyses, ultimately providing robust evidence on the efficacy and safety of RTX compared to OCR in RRMS treatment. Results are expected in 2028.
Authors
- Einar August Høgestøl (ORCID: https://orcid.org/0000-0001-8446-2111)
- Henning Hoel Rise (ORCID: https://orcid.org/0000-0002-0954-4018)
- Emmanuelle Le Page (ORCID: https://orcid.org/0000-0002-7849-2266)
- Finn Thorup Sellebjerg (ORCID: https://orcid.org/0000-0002-1333-9623)
- Bas Jasperse (ORCID: https://orcid.org/0000-0003-1577-8299)
- Øivind Torkildsen (ORCID: https://orcid.org/0000-0001-5294-2866)
- Henrik Lundell (ORCID: https://orcid.org/0000-0002-7044-442X)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Birgit I. Lissenberg‐Witte (ORCID: https://orcid.org/0000-0001-9448-1826)
- Vanessa Wiggermann (ORCID: https://orcid.org/0000-0001-5236-3039)
- Brit Ellen Rød (ORCID: https://orcid.org/0000-0003-2200-1525)
- Hartwig Roman Siebner (ORCID: https://orcid.org/0000-0002-3756-9431)
- Frank Eriksson (ORCID: https://orcid.org/0000-0003-3641-745X)
- Sahla El Mahdaoui (ORCID: https://orcid.org/0000-0003-2737-8305)
- Bob W. van Oosten (ORCID: https://orcid.org/0000-0003-4536-6201)
- Tim Friede (ORCID: https://orcid.org/0000-0001-5347-7441)
- Jeppe Romme Christensen (ORCID: https://orcid.org/0000-0002-7727-3467)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Laure Michel (ORCID: https://orcid.org/0000-0002-8119-7794)
- Gilles Edan (ORCID: https://orcid.org/0000-0002-9641-6734)
- Anne Kerbrat
- Karam Sidaros
- Zehao Su (ORCID: https://orcid.org/0000-0002-4686-5152)
- Josephine Sandahl Michelsen
- Kjell-Morten Myhr
- Malo Gaubert
- Lisa G Schoof (ORCID: https://orcid.org/0009-0005-9845-5031)
Institutions
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Haukeland University Hospital (NO)
- Frederiksberg Hospital (DK)
- Copenhagen University Hospital (DK)
- Amsterdam Neuroscience (NL)
- Universitätsmedizin Göttingen (DE)
- Danish Multiple Sclerosis Center (DK)
- Amsterdam University Medical Centers (NL)
- Centre Hospitalier Universitaire de Rennes (FR)
- Université de Rennes (FR)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.msard.2025.106858
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Sanofi
- Gilead Sciences
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- CSL Behring
- Atara Biotherapeutics
- Apellis Pharmaceuticals
- University of Oxford
- ZonMw
- Servier
- H. Lundbeck A/S
- MedDay Pharmaceuticals
- Amsterdam Neuroscience
- Sanofi Genzyme
- Daiichi Sankyo Europe
- Eurostars