Towards the development of upgrade criteria for the treatment of hidradenitis suppurativa with biologics
Current treatment practice may delay optimal intervention, potentially leading to missed therapeutic windows. A significant proportion of respondents expressed a preference for earlier biologic intervention, especially in cases of severe disease or frequent flares. The findings underscore the need for a consensus statement defining upgrade criteria for biologics as a first-line therapy, potentially improving patient outcomes and reducing healthcare burdens.
Authors
- Thrasyvoulos Tzellos (ORCID: https://orcid.org/0000-0003-2356-0847)
- K. Glasenhardt
- Angelo Valerio Marzano (ORCID: https://orcid.org/0000-0002-8160-4169)
- Christos C. Zouboulis (ORCID: https://orcid.org/0000-0003-1646-2608)
- Evangelos J. Giamarellos‐Bourboulis (ORCID: https://orcid.org/0000-0003-4713-3911)
- Niamh Kearney (ORCID: https://orcid.org/0000-0002-6469-3462)
- Joana Cabete (ORCID: https://orcid.org/0000-0003-2259-5634)
- Dillon Mintoff (ORCID: https://orcid.org/0000-0003-3705-0119)
- Giovanni Damiani (ORCID: https://orcid.org/0000-0002-2390-6505)
- Linnea Thorlacius (ORCID: https://orcid.org/0000-0002-3734-9607)
- Georgios Nikolakis (ORCID: https://orcid.org/0000-0002-0920-9092)
- Vesta Kučinskienė
- John R Ingram (ORCID: https://orcid.org/0000-0002-5257-1142)
- Piotr K. Krajewski (ORCID: https://orcid.org/0000-0003-4722-8531)
- Łukasz Matusiak (ORCID: https://orcid.org/0000-0003-2067-4929)
- Aikaterini Ι. Liakou (ORCID: https://orcid.org/0000-0003-3936-8374)
- Antonio Martorell (ORCID: https://orcid.org/0000-0003-1378-1590)
- A. Häfner (ORCID: https://orcid.org/0000-0002-2400-3922)
- Valentina Dini (ORCID: https://orcid.org/0000-0002-8537-1999)
- Hans Christian Ring (ORCID: https://orcid.org/0000-0002-6145-5549)
- Vaiva Jarienè
- Farida Benhadou (ORCID: https://orcid.org/0000-0002-4533-8297)
- Sezer Şahin (ORCID: https://orcid.org/0000-0002-0520-3945)
- Falk G. Bechara (ORCID: https://orcid.org/0000-0003-0418-521X)
- Alejandro Molina‐Leyva (ORCID: https://orcid.org/0000-0001-6882-2113)
- Raffaele Dante Caposiena (ORCID: https://orcid.org/0000-0002-0456-9582)
- V. del Mármol (ORCID: https://orcid.org/0000-0002-4359-0667)
- Flavia Manzo Margiotta (ORCID: https://orcid.org/0000-0002-9593-9357)
- Ditte Marie Lindhardt Saunte (ORCID: https://orcid.org/0000-0001-7953-1047)
- Hessel H. van der Zee (ORCID: https://orcid.org/0000-0002-2874-7726)
- Marco Romanelli (ORCID: https://orcid.org/0000-0002-4127-0141)
- Kelsey R. van Straalen (ORCID: https://orcid.org/0000-0003-3305-3814)
- E. Hristakieva (ORCID: https://orcid.org/0000-0003-0762-1072)
- Francesca Prignano (ORCID: https://orcid.org/0000-0002-5997-2045)
- Erkan Alpsoy (ORCID: https://orcid.org/0000-0001-7049-0170)
- Natalia Kirsten (ORCID: https://orcid.org/0000-0003-2390-2309)
- Tadas Raudonis (ORCID: https://orcid.org/0000-0001-8889-3859)
- Gregor B. E. Jemec (ORCID: https://orcid.org/0000-0002-0712-2540)
- Monika Arenbergerová (ORCID: https://orcid.org/0000-0002-7919-9619)
- Philippe Guillem (ORCID: https://orcid.org/0000-0002-5449-3897)
- Brian Kirby (ORCID: https://orcid.org/0000-0001-9432-8880)
- Maia Delage Toriel
Institutions
- University College Dublin (IE)
- Wrocław University of Science and Technology (PL)
- University of Copenhagen (DK)
- Our Lady of Lourdes Hospital (IE)
- Université Libre de Bruxelles (BE)
- University of Trieste (IT)
- Institut Pasteur (FR)
- Scuola Superiore Sant'Anna (IT)
- Trakia University (BG)
- Vilnius University (LT)
- Universidad de Granada (ES)
- University of Milan (IT)
- Akdeniz University (TR)
- National and Kapodistrian University of Athens (GR)
- Charles University (CZ)
- University of Szeged (HU)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Tel Aviv Sourasky Medical Center (IL)
- Frederiksberg Hospital (DK)
- Mater Dei Hospital (MT)
- Nordland Hospital Trust (NO)
- Erasmus MC (NL)
- Erasmus Hospital (BE)
- Aarhus University Hospital (DK)
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics (LT)
- Gentofte Hospital (DK)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- LMU Klinikum (DE)
- Wroclaw Medical University (PL)
- HIA du Val-de-Grâce à Paris (FR)
- Zealand University Hospital (DK)
- Ospedale Santa Chiara (IT)
- Städtisches Klinikum Dessau (DE)
- St. Vincent's University Hospital (IE)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital de Manises (ES)
- Andreas Sygros Hospital (GR)
- Società Italiana di Reumatologia (IT)
- Hôpitaux Iris Sud (BE)
- Hospital Santo António dos Capuchos (PT)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- University Hospital Kralovske Vinohrady (CZ)
- University of Florence (IT)
- AGH University of Krakow (PL)
- Cardiff University (GB)
- Ludwig-Maximilians-Universität München (DE)
- Ruhr University Bochum (DE)
- Gazi University (TR)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1111/jdv.70118
- Citations
- 4
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Celgene
- Incyte
- Celltrion
- Insmed
- National and Kapodistrian University of Athens
- Galderma
- Swedish Orphan Biovitrum
- LEO Pharma
- UCB Pharma
- Cilag