Chemoselective defluorinative amination of (trifluoromethyl)alkenes with amidines: synthesis of 6-fluoro-1,4-dihydropyrimidines
The chemoselective defluorinative amination of (trifluoromethyl)alkenes with amidines is reported. This transition-metal-free method is operationally simple and gram-scalable, tolerates diverse useful functional groups, and gives a variety of synthetically valuable 6-fluoro-1,4-dihydropyrimidines in high yields under mild conditions.
Authors
- Chuanle Zhu (ORCID: https://orcid.org/0000-0002-0096-258X)
- Han Li (ORCID: https://orcid.org/0000-0003-4638-9907)
- Xujing Long
Institutions
- South China Agricultural University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1039/d5ob01554e
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00