Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice
<i>Bmi1</i> <sup>-/-</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to <i>WT</i> mice. Our results indicate that <i>Bmi1</i> <sup>-/-</sup> mice are susceptible to HALI, and the damage increases in those mice compared with their <i>WT</i> littermates.
Authors
- Ramani Soundararajan (ORCID: https://orcid.org/0000-0001-6408-2840)
- Richard F. Lockey (ORCID: https://orcid.org/0000-0003-0279-8661)
- Venkata Ramireddy Narala (ORCID: https://orcid.org/0000-0001-6672-4165)
- Lakshmi Galam (ORCID: https://orcid.org/0000-0002-4893-7324)
- Mason Breitzig (ORCID: https://orcid.org/0000-0002-4820-3670)
- Matthew Alleyn
- Helena Hernández‐Cuervo
- Narasaiah Kolliputi (ORCID: https://orcid.org/0000-0002-1922-3533)
- Sahebgowda Sidramagowda Patil
Institutions
- University of Iowa (US)
- Pennsylvania State University (US)
- University of Miami (US)
- University of South Florida (US)
- Department of Public Health (MM)
- Penn State Milton S. Hershey Medical Center (US)
- Yogi Vemana University (IN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fphys.2025.1695456
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00