Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population
Statistically significant responses to cenobamate treatment occurred within the first 8 weeks of titration, including a 42.9% median reduction in 28-day seizure frequency (Weeks 5-6) and a seizure-free rate of 26.7% (Weeks 7-8). These data show that substantial seizure reductions occurred in many patients early during cenobamate titration.
Authors
- Huiqin Xu (ORCID: https://orcid.org/0000-0002-8856-3048)
- Julien Jung (ORCID: https://orcid.org/0000-0002-9274-0086)
- Sunita N. Misra (ORCID: https://orcid.org/0000-0002-7624-8825)
- Takamichi Yamamoto (ORCID: https://orcid.org/0000-0003-4883-1551)
- Louis Ferrari (ORCID: https://orcid.org/0000-0002-7060-6142)
- Myung Won Kim
- William E. Rosenfeld (ORCID: https://orcid.org/0000-0002-9504-3980)
- Marc Kamin
- Eun-Yeong Choe
- Jungshin Park (ORCID: https://orcid.org/0009-0004-2761-3306)
- Huapin Huang (ORCID: https://orcid.org/0000-0003-0476-756X)
- Seung Bong Hong (ORCID: https://orcid.org/0000-0002-8933-5709)
- Pranoti Pradhan (ORCID: https://orcid.org/0009-0008-4890-0645)
- Kyoung Heo (ORCID: https://orcid.org/0000-0002-0790-9837)
- Ji Hyun Kim (ORCID: https://orcid.org/0000-0003-3411-5714)
- Kensuke Kawai (ORCID: https://orcid.org/0000-0002-8218-7360)
- Sang Kun Lee (ORCID: https://orcid.org/0000-0003-1908-0699)
- Songqing Pan (ORCID: https://orcid.org/0000-0002-1103-6901)
- Yong Heui Jeon (ORCID: https://orcid.org/0000-0001-6973-684X)
- Koji Iida (ORCID: https://orcid.org/0000-0002-6234-1236)
Institutions
- Fujian Medical University (CN)
- Seoul National University (KR)
- Jichi Medical University (JP)
- Yonsei University (KR)
- Wenzhou Medical University (CN)
- Korea University Medical Center (KR)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Wuhan University (CN)
- Hanall Biopharma (South Korea) (KR)
- Seirei Mikatabara General Hospital (JP)
- Center for Children (US)
- SK Life Science (United States) (US)
- Hiroshima University Hospital (JP)
- Renmin Hospital of Wuhan University (CN)
- Korea University (JP)
- Seoul Sleep Center (KR)
- Union Hospital (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1111/epi.70012
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00