Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study
Severe CSVD score, which is associated with cortical hypoperfusion, was found to be an effective imaging marker for predicting longitudinal cognitive decline. Thus, CSVD scoring may be considered a clinically accessible tool for risk stratification and individualized health monitoring in aging populations.
Authors
- Zhentao Zuo (ORCID: https://orcid.org/0000-0002-5909-3884)
- Xiaoyuan Fan (ORCID: https://orcid.org/0000-0001-6421-855X)
- Sirui Liu (ORCID: https://orcid.org/0000-0003-4526-7924)
- Mingli Li (ORCID: https://orcid.org/0000-0001-8456-0686)
- Yicheng Zhu (ORCID: https://orcid.org/0000-0001-9667-5165)
- Chao Ma (ORCID: https://orcid.org/0000-0002-2016-8084)
- Xiaoqian Zhang
- Feng Feng (ORCID: https://orcid.org/0000-0002-3507-1154)
- Hui You (ORCID: https://orcid.org/0000-0002-6545-7787)
- Bo Hou (ORCID: https://orcid.org/0000-0003-0520-3969)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Institute of Biophysics (CN)
- Sino-Danish Centre for Education and Research (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12880-025-01967-9
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital