Fibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer
FAP-mediated alterations of ECM integrity, TC cells and CAFs underscore its potential as a powerful marker for tumor immunogenicity, immune infiltration and metastasis rendering it a promising therapeutic target for the treatment of aggressive ATC.
Authors
- Kerstin Lorenz (ORCID: https://orcid.org/0000-0003-0281-1950)
- Claudia Wickenhauser (ORCID: https://orcid.org/0000-0002-1807-5575)
- Christoforos Vaxevanis (ORCID: https://orcid.org/0000-0003-4765-1719)
- Barbara Seliger (ORCID: https://orcid.org/0000-0002-5544-4958)
- Christine Dierks (ORCID: https://orcid.org/0000-0001-9554-0912)
- Antonis Asiminas (ORCID: https://orcid.org/0000-0002-6492-0960)
- Udo Siebolts (ORCID: https://orcid.org/0000-0002-7463-9195)
- Marcus Bauer (ORCID: https://orcid.org/0000-0002-0657-6831)
- Mario Udinotti
Institutions
- University of Copenhagen (DK)
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- University Hospital Cologne (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12967-025-07307-3
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05