Primary‐Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity
Our findings reveal stage-specific mitochondrial dysfunction in CC, with early complex I impairment and a transient transcriptional adaptation in primary CC. These alterations precede clinical cachexia, suggesting mitochondrial dysfunction as a potential early biomarker for cancer-induced muscle loss and a target for early intervention.
Authors
- Sander Grefte (ORCID: https://orcid.org/0000-0002-8502-6298)
- Klaske van Norren (ORCID: https://orcid.org/0000-0002-6281-9455)
- Miranda van der Ende (ORCID: https://orcid.org/0000-0001-9864-0505)
- Rogier L.C. Plas (ORCID: https://orcid.org/0000-0002-0612-7905)
- Xiaolin Li (ORCID: https://orcid.org/0000-0001-9570-8631)
- Renger F. Witkamp (ORCID: https://orcid.org/0000-0002-7935-8261)
- Jaap Keijer (ORCID: https://orcid.org/0000-0002-9720-7491)
- Mieke Poland
- Tjarda van Heek
- Hanneke Pierre Franciscus Xaverius Moonen
- Susanne Lotstra
Institutions
- Ziekenhuis Gelderse Vallei (NL)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/jcsm.70117
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council
- Wageningen University and Research