Intratumoral <scp> <i>Fusobacterium nucleatum</i> </scp> Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma
<i>F. nucleatum</i> may contribute to the progression of ESCC by inducing NF-κB-mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, <i>F. nucleatum</i> positivity may reflect broader host vulnerability, particularly in frail elderly individuals. These findings highlight <i>F. nucleatum</i> as a potential biomarker of tumor immune dynamics and suggest the importance of maintaining good oral hygiene to reduce <i>F. nucleatum</i> colonization.
Authors
- Koshi Mimori (ORCID: https://orcid.org/0000-0003-3897-9974)
- Hajime Otsu (ORCID: https://orcid.org/0000-0002-0774-6150)
- Qingjiang Hu (ORCID: https://orcid.org/0000-0002-8313-5861)
- Takashi Ofuchi (ORCID: https://orcid.org/0000-0001-6219-5278)
- Masaaki Iwatsuki (ORCID: https://orcid.org/0000-0002-0886-4618)
- Taro Tobo
- Yoshifumi Baba (ORCID: https://orcid.org/0000-0003-3657-2388)
- Kazuki Omachi
- Kosuke Kanemitsu (ORCID: https://orcid.org/0000-0001-7054-2022)
- Yusuke Yonemura
Institutions
- University of Tokyo Hospital (JP)
- Kyushu University Beppu Hospital (JP)
- The University of Tokyo (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Annals of Gastroenterological Surgery
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1002/ags3.70116
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science