Extent of reoperation predicts survival in recurrent IDH-wildtype glioblastoma based on institutional data and individual patient data meta analysis
Across pooled IPD, maximal safe resection at re-resection operationalized as GTR or RANO class 1 and 2 was significantly associated with longer overall survival (OS). Where volumetric assessment is available, achieving a postoperative CE-RTV ≤ 1 cm<sup>3</sup> may be a reasonable pragmatic target, however this threshold was not directly measured in all included cohorts and should be interpreted as hypothesis-generating.
Authors
- Johannes Wach (ORCID: https://orcid.org/0000-0002-4680-0412)
- Alim Emre Basaran
- Ann-Catalin Wellkisch
Institutions
- University Hospital Leipzig (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1007/s12672-025-03928-8
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00