AC/DC: Highway to cell
Apoptotic cell (AC) corpses can be taken up by certain types of dendritic cell (DC), which cross-present dead cell-derived antigens. In this issue of JEM, Tam et al. (https://doi.org/10.1084/jem.20250887) reveal that GPR34, a lysophosphatidylserine receptor, promotes AC uptake and cross-presentation by type 1 DCs (cDC1s).
Authors
- Victor Bosteels (ORCID: https://orcid.org/0000-0001-8838-021X)
- Caetano Reis e Sousa (ORCID: https://orcid.org/0000-0001-7392-2119)
- William Stainier (ORCID: https://orcid.org/0009-0003-6182-4003)
Institutions
- The Francis Crick Institute (GB)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1084/jem.20251958
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00