Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal

This study demonstrates that anabolic steroid administration markedly increases the risk of GCT in Arabian mares. Behavioral changes, ultrasonographic appearance, and hormonal profiles remain key diagnostic indicators, while histopathology confirms tumor classification. Surgical excision proved effective, with favorable fertility outcomes in most mares. These findings underscore the importance of early diagnosis and highlight the need for judicious use of anabolic steroids in breeding programs.

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Publication Details

Journal
Frontiers in Veterinary Science
Published
2025-11-13
DOI
https://doi.org/10.3389/fvets.2025.1689782
Primary Topic
Reproductive Physiology in Livestock
Type
article
Field-Weighted Citation Impact
0.00

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article

Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal

Walid Refaai, Ahmed Ali, Fahd Al-Sobayil, Derar Derar
Frontiers in Veterinary Science
Reproductive Physiology in Livestock
article

Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal

Walid Refaai, Ahmed Ali, Fahd Al-Sobayil, Derar Derar
article en

Abstract

This study demonstrates that anabolic steroid administration markedly increases the risk of GCT in Arabian mares. Behavioral changes, ultrasonographic appearance, and hormonal profiles remain key diagnostic indicators, while histopathology confirms tumor classification. Surgical excision proved effective, with favorable fertility outcomes in most mares. These findings underscore the importance of early diagnosis and highlight the need for judicious use of anabolic steroids in breeding programs.

Frontiers in Veterinary ScienceVol. 12
Qassim University (SA), Zagazig University (EG), Buraydah Colleges (SA)
Qassim University
Openalex Percentile: Top 56%
Reproductive Physiology in Livestock
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Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal — Walid Refaai, Ahmed Ali, et al. · Frontiers in Veterinary Science (2025) | TGRS Research Map | TGRS