CoFe2O4-Based Multifunctional Nanozymes Remodel Tumor Redox Balance for Enhanced Osteosarcoma Treatment
The CF@P nanozyme integrates the properties of multi-enzyme catalysis and photothermal therapy, disrupting the oxidative-redox homeostasis of tumor tissues, generating highly toxic hydroxyl radicals, and efficiently inducing apoptosis in osteosarcoma cells. This approach provides a new, efficient, and safe strategy for the precise treatment of hypoxic solid tumors like osteosarcoma.
Authors
- Hongmei Gu (ORCID: https://orcid.org/0000-0002-8572-5435)
- Yong Hu (ORCID: https://orcid.org/0000-0002-5394-6743)
- Shuheng Qin
- Jianhua Xue (ORCID: https://orcid.org/0000-0002-1595-3803)
- Yang� Yang (ORCID: https://orcid.org/0000-0003-1222-1209)
- Qiang Xue (ORCID: https://orcid.org/0000-0002-0493-5685)
- Xianchen Liu (ORCID: https://orcid.org/0000-0002-4325-2545)
- Jiajia Liu
Institutions
- Nanjing Tech University (CN)
- China Pharmaceutical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/ijn.s556295
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67