Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution
This study led to the development of two metabolically stable GRPR-targeting radiopeptides, [<sup>177</sup>Lu]Lu-PKB2 and [<sup>177</sup>Lu]Lu-PKB3, with a high potential for targeted radionuclide therapy.
Authors
- Ekaterina Bezverkhniaia (ORCID: https://orcid.org/0000-0001-7699-5719)
- Panagiotis Kanellopoulos (ORCID: https://orcid.org/0000-0002-0617-3936)
- Anna Orlova (ORCID: https://orcid.org/0000-0001-9262-7529)
- Vladimir Tolmachev (ORCID: https://orcid.org/0000-0002-6122-1734)
- Karim Obeid
Institutions
- Uppsala University (SE)
- Science for Life Laboratory (SE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s41181-025-00402-2
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36