Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats
The gastrointestinal tract is at persistent risk to develop tissue injury during hemorrhagic shock. The systemic application of PDTC is a promising pharmacological strategy to improve intestinal oxygen reserve during hemorrhagic shock and subsequent blood transfusion. This might lead to reduced intestinal tissue injury, maintain global homeostasis and reduce morbidity of patients suffering from hemorrhagic shock. However, the exact mechanism by which PDTC pretreatment improves intestinal oxygen reserve has to be elucidated in further studies since neither microvascular nor mitochondrial function was altered after PDTC application in this study. Furthermore, observed effects might include both HO-1-dependent and HO-1-independent mechanisms.
Authors
- Carsten Marcus (ORCID: https://orcid.org/0009-0007-5993-9417)
- Anna Herminghaus (ORCID: https://orcid.org/0000-0001-6371-392X)
- Stefan Hof
- Anne Kuebart (ORCID: https://orcid.org/0000-0001-8083-5873)
- O. Picker (ORCID: https://orcid.org/0000-0002-6155-589X)
- Christopher Neumann (ORCID: https://orcid.org/0009-0000-9009-8678)
- Borna Relja (ORCID: https://orcid.org/0000-0002-5625-8823)
- Joachim P. Schmitt (ORCID: https://orcid.org/0000-0001-5742-1680)
- Inge Bauer (ORCID: https://orcid.org/0000-0001-5223-9898)
- Richard Truse (ORCID: https://orcid.org/0000-0001-6650-5800)
- Christian Vollmer (ORCID: https://orcid.org/0000-0002-2646-5629)
- Leandra Krüll
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Düsseldorf University Hospital (DE)
- University Hospital Ulm (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12967-025-07413-2
- Citations
- 1
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 1.15