Clozapine Drug–Drug Interactions and Individualized Dosing in Bipolar Disorder: A Model-Informed Precision Dosing Approach
This study explores the DDI of clozapine in patients with BD based on MIPD, and recommends the individualized dosing regimen of clozapine in patients with BD according to concomitant medication. These findings provide weight- and drug-specific dosing recommendations that may improve the safety and efficacy of clozapine in BD patients.
Authors
- Xue Tian (ORCID: https://orcid.org/0000-0001-6162-2856)
- Su‐Mei He
- Yi-Jia Zhang
- Ye Li (ORCID: https://orcid.org/0000-0002-1624-8831)
- Xiao Chen (ORCID: https://orcid.org/0000-0002-0386-3675)
- Jie Wang (ORCID: https://orcid.org/0000-0002-7351-8332)
- Dongdong Wang (ORCID: https://orcid.org/0000-0002-4019-5530)
- Cun Zhang (ORCID: https://orcid.org/0000-0002-9381-9730)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-8463-0223)
Institutions
- Xuzhou Medical College (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/dddt.s557624
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00