Interventional Treatment vs Conservative Management of Unruptured Brain Arteriovenous Malformations
In this nationwide cohort study using target trial emulation, interventional treatment of unruptured AVMs was associated with improved hemorrhage-free survival at 5 and 10 years. These findings support individualized decision-making in the management of unruptured AVMs and demonstrate how target trial emulation can inform clinical questions where randomized clinical trials are not feasible.
Authors
- Changyu Lu (ORCID: https://orcid.org/0000-0002-4839-7671)
- Xiangyu Meng (ORCID: https://orcid.org/0000-0002-7703-1177)
- Shuai Kang (ORCID: https://orcid.org/0000-0003-4123-9512)
- Zhiyong Shi (ORCID: https://orcid.org/0000-0003-3392-0041)
- Ruinan Li (ORCID: https://orcid.org/0000-0003-2177-8076)
- Junlin Lu (ORCID: https://orcid.org/0000-0003-4879-0729)
- Xiaofeng Chao
- Ke Wang (ORCID: https://orcid.org/0000-0003-1255-8047)
- Weitao Jin (ORCID: https://orcid.org/0000-0001-6825-5657)
- Xun Ye (ORCID: https://orcid.org/0000-0002-1321-0942)
- Li Ma (ORCID: https://orcid.org/0000-0003-0894-7867)
- Runting Li (ORCID: https://orcid.org/0000-0002-3096-7197)
- Heze Han (ORCID: https://orcid.org/0000-0001-9155-038X)
- Yahui Zhao (ORCID: https://orcid.org/0000-0001-8309-2104)
- Hengwei Jin (ORCID: https://orcid.org/0000-0002-6830-6300)
- Yunfan Zhou (ORCID: https://orcid.org/0000-0002-0889-5211)
- Zhengfeng Lin
- Qinghui Zhu
- Fa Lin (ORCID: https://orcid.org/0000-0001-8705-2652)
- Tengfei Yu
- Qiang Wang (ORCID: https://orcid.org/0000-0001-6686-6630)
- Yingying Su (ORCID: https://orcid.org/0000-0002-4532-512X)
- Chengzhuo Wang (ORCID: https://orcid.org/0009-0002-2106-5818)
- Zhipeng Li (ORCID: https://orcid.org/0000-0003-3190-2253)
- Haibin Zhang (ORCID: https://orcid.org/0000-0003-0366-4040)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-3665-4351)
- Yú Chen (ORCID: https://orcid.org/0000-0003-2491-3974)
- Hao Wang (ORCID: https://orcid.org/0000-0002-9131-0199)
- Jun Pu (ORCID: https://orcid.org/0009-0006-0478-4246)
- Kexin Yuan (ORCID: https://orcid.org/0000-0002-0937-2711)
- Xiaolin Chen (ORCID: https://orcid.org/0000-0001-6756-3391)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-4919-5390)
- Yukun Zhang (ORCID: https://orcid.org/0000-0003-4487-9988)
- Debin Yan
- Shibin Sun (ORCID: https://orcid.org/0000-0002-8081-6768)
- Youxiang Li (ORCID: https://orcid.org/0009-0004-8962-8079)
- Qiang Hao (ORCID: https://orcid.org/0000-0001-7075-8237)
- Dezhi Gao
- Weiwei Chen (ORCID: https://orcid.org/0000-0002-9581-0502)
- Yuanli Zhao (ORCID: https://orcid.org/0000-0002-3096-7197)
- Cunyang Li
- Anqi Li (ORCID: https://orcid.org/0000-0003-2156-0384)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-2542-4734)
Institutions
- Xuzhou Medical College (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beibu Gulf University (CN)
- Beijing Institute of Neurosurgery (CN)
- Peking University International Hospital (CN)
- University of Pittsburgh Medical Center (US)
- Shanxi Provincial Children's Hospital (CN)
- Neurological Surgery (US)
- Artificial Intelligence in Medicine (Canada) (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.43408
- Citations
- 1
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China