Genetic and environmental contributions to variation in plasma phosphorylated tau 217
Phosphorylated tau (p-tau)217 concentrations are substantially heritable (> 41%). Genetic contributions to variation in plasma p-tau217 were found to be sex specific. Genetic and environmental correlations were found between p-tau217 and Alzheimer's disease biomarkers. P-tau217 reflects different processes in cognitively unimpaired males and females.
Authors
- David H. Wilson (ORCID: https://orcid.org/0000-0001-8322-0380)
- Conor V. Dolan (ORCID: https://orcid.org/0000-0002-2496-8492)
- Rebecca Z. Rousset (ORCID: https://orcid.org/0000-0001-9355-7286)
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Eco J. C. de Geus (ORCID: https://orcid.org/0000-0001-6022-2666)
- Lannie Ligthart (ORCID: https://orcid.org/0000-0002-6570-3319)
- Lisanne in ‘t Veld
Institutions
- Amsterdam Neuroscience (NL)
- Quanterix (United States) (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70906
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Alzheimer's Association
- EU Joint Programme – Neurodegenerative Disease Research
- International Progressive MS Alliance
- Multiple Sclerosis Society
- European Commission
- ZonMw
- Vrije Universiteit Amsterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland
- FP7 Health