Blood‐based Alzheimer's disease biomarkers in a behavioral neurology clinic: Real‐world implementation, clinical utility, and diagnostic performance
Blood-based biomarkers (BBMs) were quickly adopted and accelerated precision diagnosis in a large memory clinic. BBM use cases were diverse and included all stages/types of AD and non-AD syndromes. Plasma p-tau has the potential to impact diagnostic certainty and clinical decision making. Diagnostic performance of p-tau is reasonable, though renal function impacts overall accuracy.
Authors
- Lawren VandeVrede (ORCID: https://orcid.org/0000-0002-8304-6711)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Yingbing Wang
- Peter Alexander Ljubenkov (ORCID: https://orcid.org/0000-0002-3348-9215)
- Nhat Bui (ORCID: https://orcid.org/0009-0000-8532-7464)
- Melanie L. Stephens (ORCID: https://orcid.org/0000-0002-2744-6489)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Elena Tsoy (ORCID: https://orcid.org/0000-0001-8786-1791)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Gautam Tammewar
- David N. Soleimani‐Meigooni (ORCID: https://orcid.org/0000-0003-4197-3039)
- Manizhe Eslami‐Amirabadi (ORCID: https://orcid.org/0000-0002-2166-2439)
- Igor Araújo (ORCID: https://orcid.org/0000-0002-9226-7321)
- Kaancan Deniz (ORCID: https://orcid.org/0000-0002-5496-0598)
- Charles Windon (ORCID: https://orcid.org/0000-0001-8719-1206)
- Andrew G. Breithaupt (ORCID: https://orcid.org/0000-0003-3955-5428)
- Katherine L. Possin (ORCID: https://orcid.org/0000-0002-6623-3793)
- Connor D. Dietz (ORCID: https://orcid.org/0000-0002-0122-3295)
- Marci F. Rosenberg
- Adam L. Boxer
- Y. González González
- Tara Ellingson
- Nicholas U. Schwartz (ORCID: https://orcid.org/0000-0003-1040-7819)
Institutions
- Emory University (US)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70891
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00