Association of GAS6, AXL, and GAS6-AS lncRNAs with nephropathy in Egyptian patients with type 2 diabetes mellitus: a case–control observational study
The current findings emphasize the significance of the GAS6/AXL pathway in DM and DN progression, where GAS6, AXL, and GAS6-DT showed significantly altered values in DM, and further in DN, with notable diagnostic power for both diseases. To date, this is the first study confirming the diagnostic power of AXL and GAS6-DT in DN and DM. Future studies are warranted to evaluate therapeutically targeting this pathway to manage DN.
Authors
- Tarek K. Motawi (ORCID: https://orcid.org/0000-0001-8925-9702)
- Nancy N. Shahin (ORCID: https://orcid.org/0000-0002-9746-5335)
- Dina Sabry (ORCID: https://orcid.org/0000-0002-6720-3385)
- Nancy Mamdouh Ahmed (ORCID: https://orcid.org/0000-0003-4490-8793)
Institutions
- Cairo University (EG)
- Nahda University (EG)
- Badr University in Cairo (EG)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1038/s41387-025-00400-y
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund