Female Sex and Mortality in Patients With Gram-Negative Bacteremia
In this systematic review and meta-analysis, female patients with GN-BSI were not at higher risk than male patients of mortality after statistical adjustment. GN-BSI and SA-BSI thus differ in sex-specific mortality outcomes, highlighting the need for further research into the immunological, pathophysiological, and clinical management factors that may be associated with sex disparities in SA-BSI but not in GN-BSI.
Authors
- Divyam Goel (ORCID: https://orcid.org/0000-0002-5281-4255)
- George Davey Smith (ORCID: https://orcid.org/0000-0002-1407-8314)
- Stacey A. Maskarinec (ORCID: https://orcid.org/0000-0002-1716-8374)
- Annette C. Westgeest (ORCID: https://orcid.org/0000-0002-0648-3555)
- Steven D. Keller
- Vance G. Fowler (ORCID: https://orcid.org/0000-0002-8048-0897)
- Madhukar S. Patel (ORCID: https://orcid.org/0000-0001-7508-899X)
- P. Cox (ORCID: https://orcid.org/0000-0002-4636-5668)
- Joshua B. Parsons (ORCID: https://orcid.org/0000-0002-0589-3587)
- Merel M. C. Lambregts (ORCID: https://orcid.org/0000-0003-3637-9115)
- Roberta Monardo (ORCID: https://orcid.org/0000-0002-1388-4322)
- Felicia Ruffin (ORCID: https://orcid.org/0000-0003-2176-6462)
- Sarah Cantrell (ORCID: https://orcid.org/0000-0003-2694-7836)
- Joshua T. Thaden (ORCID: https://orcid.org/0000-0002-3250-0697)
- Yazhong Tao
- Rachel E. Korn (ORCID: https://orcid.org/0009-0007-2239-0870)
- Priscilla La (ORCID: https://orcid.org/0009-0005-7724-4753)
- Jean Francois Jabbour
Institutions
- Vita-Salute San Raffaele University (IT)
- Duke University (US)
- Leiden University Medical Center (NL)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.43552
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- AstraZeneca
- Universiteit Leiden
- Leids Universitair Medisch Centrum
- National Institutes of Health
- Janssen Pharmaceuticals