Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?
Serum p-tau217, across multiple platforms, shows strong correlations with plasma p-tau217 and reflected comparable patterns across the AD continuum. However, absolute concentrations differed for most assays, thus requiring differing disease specific cutoffs. Most of the evaluated platforms demonstrated reliable quantification of p-tau217 in serum, yielding satisfactory validation performance. These findings support serum as a viable alternative to plasma for p-tau217 quantification in both research and clinical settings, provided matrix-specific validation is ensured.
Authors
- Guglielmo Di Molfetta (ORCID: https://orcid.org/0009-0001-5339-933X)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Hanna Huber (ORCID: https://orcid.org/0009-0004-3080-6870)
- Hlin Kvartsberg (ORCID: https://orcid.org/0000-0002-4481-508X)
- Burak Arslan (ORCID: https://orcid.org/0000-0001-7229-3226)
- Anna Orduña Dolado (ORCID: https://orcid.org/0009-0003-8287-0754)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Ilaria Pola (ORCID: https://orcid.org/0000-0003-2090-2944)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Andréa L. Benedet
- Shorena Janelidze
- Kaj Blennow
- Kübra Tan (ORCID: https://orcid.org/0000-0002-9092-2118)
Institutions
- University of Science and Technology of China (CN)
- Montreal Neurological Institute and Hospital (CA)
- University of Wisconsin–Madison (US)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Banner Health (US)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- Institut du Cerveau (FR)
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/clinchem/hvaf162
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33