Epigenetic regulation of varicella-zoster virus infection: a systematic synthesis of mechanisms
This review elucidates the intricate, reciprocal crosstalk between epigenetic regulation and immune responses in VZV infection. Our findings highlight the understudied nature of VZV epigenetics despite its clinical significance and reveal key nodes within the immune-epigenetic network as promising, clinically actionable therapeutic targets for improving HZ management. This synthesis provides a crucial translational framework for developing epigenetically informed interventions to control viral reactivation and mitigate disease burden.
Authors
- Lei Peng (ORCID: https://orcid.org/0000-0002-1162-1473)
- Chaofeng Han (ORCID: https://orcid.org/0000-0002-8489-6478)
- Honghao Song (ORCID: https://orcid.org/0009-0001-9838-5273)
- Yanjing Chen (ORCID: https://orcid.org/0000-0001-9211-4993)
- Hongbin Yuan (ORCID: https://orcid.org/0000-0001-8468-4005)
- Kaiqiang Sun (ORCID: https://orcid.org/0000-0002-0272-8383)
- Tianhao Li (ORCID: https://orcid.org/0000-0001-9500-6584)
- Yuqing Ma (ORCID: https://orcid.org/0009-0007-7293-9980)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Naval University of Engineering (CN)
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1097/js9.0000000000003912
- Citations
- 2
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.71