A prospective single-center cohort study: integrating PET imaging and genomics to identify early biomarkers of response to dual-targeted PH neoadjuvant therapy in breast cancer
The study underscores the significance of early biomarkers in predicting neoadjuvant treatment outcomes for HER2-positive breast cancer. Integrating genomic and imaging data provides a comprehensive approach for tailoring therapeutic strategies. The identified biomarkers hold promise for guiding treatment escalation or de-escalation, presenting a step forward in personalized management for HER2-positive breast cancer patients.
Authors
- Ying Qiao (ORCID: https://orcid.org/0000-0003-4308-5633)
- Bingqiu Xiu (ORCID: https://orcid.org/0000-0002-0771-591X)
- Jingyan Xue (ORCID: https://orcid.org/0009-0005-2374-9588)
- Jiong Wu
- Panli Li
- Shaoli Song (ORCID: https://orcid.org/0000-0003-2544-7522)
- Zhimin Shao
- Jianping Zhang (ORCID: https://orcid.org/0000-0001-7802-8933)
- Xiao Xiao (ORCID: https://orcid.org/0000-0002-4328-0634)
- Jing Bai (ORCID: https://orcid.org/0009-0001-2542-0795)
- Xiaoping Xu (ORCID: https://orcid.org/0000-0001-9656-6233)
- Yuyun Sun (ORCID: https://orcid.org/0000-0001-8823-2698)
- Ming Chen (ORCID: https://orcid.org/0009-0002-6617-2019)
- Benlong Yang
Institutions
- BGI Group (China) (CN)
- Shanghai Medical College of Fudan University (CN)
- Peking University (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/js9.0000000000003931
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00