Polygenic prediction of coronary heart disease among 130 000 Mexican adults
In this Mexican population, existing PRSs predicted CHD independently of established vascular risk factors, particularly for men. PRSs better capturing genetic variation in Latin American people may further enhance risk prediction in such populations.
Authors
- Alejandra Vergara (ORCID: https://orcid.org/0009-0004-7036-144X)
- Michael Hill (ORCID: https://orcid.org/0000-0002-3861-6105)
- Pablo Antonio Kuri-Morales (ORCID: https://orcid.org/0000-0002-0704-9507)
- Fiona Bragg (ORCID: https://orcid.org/0000-0002-9181-6886)
- Jonathan Emberson (ORCID: https://orcid.org/0000-0001-7792-9422)
- Jason Torres (ORCID: https://orcid.org/0000-0002-7537-7035)
- Jesús Alegre-Díaz (ORCID: https://orcid.org/0000-0001-9390-3871)
- Jaime Berúmen (ORCID: https://orcid.org/0000-0001-6707-3317)
- Raúl Ramírez-Reyes (ORCID: https://orcid.org/0000-0001-9763-324X)
- Paulina Baca (ORCID: https://orcid.org/0000-0002-0617-5931)
- Diego J. Aguilar-Ramirez (ORCID: https://orcid.org/0000-0003-2298-3768)
- William Guy Herrington (ORCID: https://orcid.org/0000-0003-1172-8243)
- Carlos González-Carballo (ORCID: https://orcid.org/0000-0001-5110-1563)
- Louisa Gnatiuc (ORCID: https://orcid.org/0000-0002-0641-2220)
- Fernando Rivas
- Eirini Trichia (ORCID: https://orcid.org/0000-0002-7655-5905)
- Rory Collins (ORCID: https://orcid.org/0000-0001-8288-8602)
- Rachel Wade (ORCID: https://orcid.org/0000-0001-9826-6322)
- Roberto Tapia‐Conyer (ORCID: https://orcid.org/0000-0003-3814-2904)
- Tianshu Liu (ORCID: https://orcid.org/0000-0002-0897-1974)
Institutions
- Centro Universitario Anglo Mexicano (MX)
- University of Oxford (GB)
- Nuffield Health (GB)
- Health Data Research UK (GB)
- Science Oxford (GB)
- Universidad Nacional Autónoma de México (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1093/eurjpc/zwaf728
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- AstraZeneca
- Regeneron Pharmaceuticals
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- University of Oxford
- Universidad Nacional Autónoma de México
- Medical Research Council