Natural origin microfiber scaffolds from microfluidic spinning for gastric tumor postsurgical treatment

The PMs@HCS scaffold was designed to eliminate residual cancer and promote gastric repair. • A Huachansu-loaded Premna Microphylla microfiber scaffold was fabricated by microfluidic spinning. • The scaffold effectively inhibits tumor recurrence and improves survival in gastric cancer models. • The bioactive scaffold supports post-surgical gastric tissue regeneration. Biomedical scaffolds have recently emerged as promising postoperative treatment platforms in the field of oncology. In this study, we propose novel natural-origin scaffolds encapsulating Huachansu (HCS) to treat gastric cancer (GC) in postsurgical. The scaffold, characterized by a well-woven mesh structure, is fabricated using microfluidic spinning and ion cross-linking of Premna Microphylla (PM), a Chinese medicine derived from herbs. These natural-origin ingredients enable the scaffolds with good biocompatibility. In a GC post-surgical model in nude mice, the microfiber scaffolds could significantly inhibit GC tumor recurrence following tumor resection. Furthermore, the natural-origin scaffolds could effectively repair stomach damage in the gastrotomy model. Given these promising features, the natural-origin microfiber scaffolds hold significant potential in biomedicine, particularly in comprehensive post-surgical treatments for GC.