Integrating bulk and single-cell RNA sequencing analysis to reveal characterization of mechanical stimulus-related genes and prognostic signatures in breast cancer
We developed a pioneering prognostic signature incorporating MSRGs in breast cancer, with a particular focus on mechanical stimuli may influence breast cancer prognosis by remodeling the immune microenvironment. The findings highlighted the importance of personalized treatment strategies and provide new insights into the role of mechanical forces in breast tumor biology.
Authors
- Yandi Sun
- Yindan Lin
- Haifeng Lou (ORCID: https://orcid.org/0000-0002-6578-100X)
- Jiang Zhu (ORCID: https://orcid.org/0000-0001-9764-8281)
- Zhu Gao (ORCID: https://orcid.org/0000-0002-0550-0325)
- Yingfei Huang (ORCID: https://orcid.org/0000-0002-4529-5936)
- Yuqiong Huang (ORCID: https://orcid.org/0000-0002-9193-1892)
- Lingyun Guo (ORCID: https://orcid.org/0000-0003-0204-6961)
- Jingjia Li (ORCID: https://orcid.org/0000-0003-4561-1537)
- Ze Yang (ORCID: https://orcid.org/0000-0003-3195-7393)
Institutions
- Zhejiang Chinese Medical University (CN)
- University of Kentucky (US)
- Fudan University (CN)
- Ningbo No. 2 Hospital (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s13058-025-02130-6
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00