Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery − a secondary analysis of the CYBER-SPACE randomized phase 2 trial
BMV was the only score able to predict both OS and WBRTi across all tumor types. Two distinct endpoint-specific BMV cut-offs may support clinical decision-making between continued SRS and early WBRT, but warrant further external validation.
Authors
- Rami A. El Shafie (ORCID: https://orcid.org/0000-0002-1355-7882)
- Kristin Lang (ORCID: https://orcid.org/0000-0002-5355-3173)
- Thomas Welzel (ORCID: https://orcid.org/0000-0001-9960-3052)
- Farastuk Bozorgmehr (ORCID: https://orcid.org/0000-0001-8058-8884)
- A. Lentz-Hommertgen
- Laila König (ORCID: https://orcid.org/0000-0001-8402-6694)
- Michael Nikolaus Thomas (ORCID: https://orcid.org/0000-0002-4121-3091)
- Denise Bernhardt (ORCID: https://orcid.org/0000-0001-5231-9097)
- Stefan Rieken (ORCID: https://orcid.org/0009-0000-7018-2856)
- Annabella Schiele
- Anna Krämer (ORCID: https://orcid.org/0000-0002-3174-7524)
- Fabian Weykamp (ORCID: https://orcid.org/0000-0003-1731-7090)
- Tanja Eichkorn (ORCID: https://orcid.org/0000-0003-0150-1328)
- Paul Thalmann
- Jürgen Debus
- Anja Sander
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Zimmer Biomet (Germany) (DE)
- National Center for Tumor Diseases (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1016/j.radonc.2025.111279
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Accuray