From retina to brain: how deep learning closes the gap in silent stroke screening

Silent brain infarctions (SBIs), affecting 20% of adults and increasing stroke risk, evade routine MRI screening. While retinal scans offer a “window to the brain,” prior AI failed to simultaneously detect SBIs and predict strokes. DeepRETStroke overcomes this by analysing eye scans. Trained on ~900,000 images, it uses deep learning combining self-supervised pattern recognition from unlabeled images, semi-supervised SBI detection with limited MRI, and knowledge transfer refinement, transforming eye exams into affordable stroke screenings.

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Publication Details

Journal
npj Digital Medicine
Published
2025-11-13
DOI
https://doi.org/10.1038/s41746-025-02021-2
Citations
1
Primary Topic
Retinal Imaging and Analysis
Type
article
Field-Weighted Citation Impact
1.36

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article

From retina to brain: how deep learning closes the gap in silent stroke screening

Y S Wang, Shumao Xu, Mingyuan Ge
1 citations
npj Digital Medicine
Retinal Imaging and Analysis
1.36
article

From retina to brain: how deep learning closes the gap in silent stroke screening

Y S Wang, Shumao Xu, Mingyuan Ge
article en
1 citations

Abstract

Silent brain infarctions (SBIs), affecting 20% of adults and increasing stroke risk, evade routine MRI screening. While retinal scans offer a “window to the brain,” prior AI failed to simultaneously detect SBIs and predict strokes. DeepRETStroke overcomes this by analysing eye scans. Trained on ~900,000 images, it uses deep learning combining self-supervised pattern recognition from unlabeled images, semi-supervised SBI detection with limited MRI, and knowledge transfer refinement, transforming eye exams into affordable stroke screenings.

npj Digital MedicineVol. 8(1)
Fudan University (CN), Shanghai Institute for Science of Science (CN), Huashan Hospital (CN), Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
National Natural Science Foundation of China, Fudan University
Openalex Percentile: Top 14%
Retinal Imaging and Analysis
1.36
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