Integrated analysis of fecal microbiota and metabolomics reveals unique characteristics of asymptomatic and classic celiac disease
In conclusion, different CeD subtypes may involve a "host-microbe-metabolite" trinity network: A random forest model built with SCeD-CDFH differential microbes/metabolites is a high-efficacy SCeD diagnostic tool; modulating these microbes/metabolites could be a new entry point for CeD mechanism research and adjunctive therapy.
Authors
- Tian Shi (ORCID: https://orcid.org/0000-0002-7173-9502)
- Feng Gao (ORCID: https://orcid.org/0000-0002-5548-5055)
- Halina Halike
- Munila Maimaiti
- Ayinuer Maimaitireyimu
- Na Li (ORCID: https://orcid.org/0000-0001-6163-1648)
- Yan Feng
- Shenglong Xue (ORCID: https://orcid.org/0009-0009-0650-8300)
- Shanxia Yao
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fmicb.2025.1636007
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang