The feasibility of human embryonic stem cell (hESC)-derived cartilage for tracheoplasty
Cartilage tissue derived from hESCs successfully maintained airway structure and biocompatibility in a rat model for three months, which supports the application of engineered cartilage for clinical airway reconstruction.
Authors
- Kazuto Hoshi (ORCID: https://orcid.org/0000-0001-5520-7488)
- Akihiro Umezawa (ORCID: https://orcid.org/0000-0002-0485-6653)
- Makoto Komura (ORCID: https://orcid.org/0000-0002-8905-8019)
- Ren Itou
- Shin Enosawa (ORCID: https://orcid.org/0000-0002-0818-8998)
- Junlong Chen
- Yasushi Fuchimoto (ORCID: https://orcid.org/0000-0003-3580-3359)
- Hidenori Akutsu
Institutions
- University of Tokyo Hospital (JP)
- National Center For Child Health and Development (JP)
- The University of Tokyo (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.reth.2025.11.005
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00