Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young
Obstructive sleep apnea (OSA) has been strongly linked to increased cardiovascular risk and poor glycemic control in the general population. Resting heart rate (RHR) is a prognostic marker of cardiovascular morbidity and mortality and has been linked to dysglycemia. Little is known about OSA, RHR, and glycemia in maturity-onset diabetes of the young (MODY), an inherited form of diabetes with discrete clinical features. Adults with transcription factor-related MODY (HNF1A, HNF4A, and HNF1B) had more OSA and higher RHR and greater glycemic variability compared with those with glucokinase-MODY or control adults without diabetes, which may have important clinical implications for future cardiovascular risk.
Authors
- Maria V. Salguero (ORCID: https://orcid.org/0000-0002-7267-6603)
- Kristen Wroblewski (ORCID: https://orcid.org/0000-0001-9297-0394)
- Esra Tasali
- Rochelle N. Naylor (ORCID: https://orcid.org/0000-0003-1753-8328)
- Louis H. Philipson (ORCID: https://orcid.org/0000-0002-2208-3607)
- Karishma Chopra
- Demetra Reyes
- Marilyn Arosemena (ORCID: https://orcid.org/0000-0002-8185-4707)
Institutions
- Chicago Department of Public Health (US)
- Universidad Espíritu Santo (EC)
- University of Chicago (US)
- Texas Diabetes Institute (US)
- Advocate Children's Hospital (US)
- Advocate Children's Hospital (US)
- Adler University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-13
- DOI
- https://doi.org/10.2337/db24-0787
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Chicago
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases