Inhibition of ADORA3 Accelerates Hematoma Resolution and Neurological Recovery after ICH
The inhibition of ADORA3 by MRS1523 promoted phagocytosis of microglia on erythrocytes, accelerating hematoma clearance after ICH, reducing the damage of neurons and neuroinflammation around the hematoma, and ultimately promoting neurological recovery.
Authors
- Xian Yu (ORCID: https://orcid.org/0000-0001-7059-0390)
- Yu Qi (ORCID: https://orcid.org/0000-0001-8029-2207)
- Guannan Guan
- Lingxin Cai
- Huaping Huang (ORCID: https://orcid.org/0000-0002-0534-2718)
- Fengqi Zhou (ORCID: https://orcid.org/0000-0003-4070-8153)
- Chao Ding (ORCID: https://orcid.org/0000-0002-4575-301X)
- Yirui Kuang
- Jiahao Zhang (ORCID: https://orcid.org/0009-0005-5105-250X)
- Qi Zhu (ORCID: https://orcid.org/0000-0002-4325-0769)
- Linfeng Fan
- Jiayin Zhou (ORCID: https://orcid.org/0009-0002-3269-0723)
- Yonghe Zheng
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Cerebrovascular Diseases
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1159/000549241
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00