Breast cancer progression in the presence of treated and untreated left ventricular dysfunction
Specific HF treatments can mitigate cancer growth in a mouse model of MI-induced LV dysfunction, with outcomes varying by treatment. These benefits occurred only with LV dysfunction, suggesting they result from changes in HF pathophysiology rather than direct drug effects on tumor cells. Restoration of immune signaling may contribute to these effects.
Authors
- Céline Civati
- Juliane Ott
- Vincent F. M. Segers (ORCID: https://orcid.org/0000-0001-7796-2222)
- Steven Van Laere (ORCID: https://orcid.org/0000-0002-2640-0040)
- Bo Goovaerts
- Siel Van den Bogaert
- B Van Berlo
- Gilles W. De Keulenaer (ORCID: https://orcid.org/0000-0002-4238-4183)
Institutions
- University of Antwerp (BE)
- Antwerp University Hospital (BE)
- Province of Antwerp (BE)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s40959-025-00400-y
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vlaamse Interuniversitaire Raad
- Universiteit Antwerpen
- Vlaamse regering