Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway
TsSPc binding to CK8 receptor in gut epithelium activated RhoA/ROCK1 pathway, reduced TJs expression and disrupted gut epithelial integrity, therefore mediated larval invasion of host gut mucosa. TsSPc might be considered as a promising vaccine molecular target for intercepting T. spiralis invasion and infection.
Authors
- Ruo Dan Liu (ORCID: https://orcid.org/0000-0003-3451-9540)
- Xin Zhuo Zhang (ORCID: https://orcid.org/0009-0003-3576-8220)
- Jing Cui (ORCID: https://orcid.org/0000-0001-8726-5498)
- Wen Wen Zheng
- Xi Zhang (ORCID: https://orcid.org/0000-0001-6148-8837)
- Ru Zhang (ORCID: https://orcid.org/0009-0000-2209-2039)
- Shao Rong Long
- Zhong Quan Wang (ORCID: https://orcid.org/0000-0001-9376-9975)
- Pei Kun Cong
Institutions
- Zhengzhou University (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1371/journal.pntd.0013725
- Citations
- 1
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40