High-dose intravenous iron significantly reduces the risk of red blood cell transfusion and improves postoperative hemoglobin levels after cardiac surgery: A systematic review of randomized controlled trials

High-dose intravenous iron supplementation during the perioperative period of cardiac surgery significantly reduces the risk of red blood cell transfusion and enhances postoperative hemoglobin levels. Although the present study demonstrated a favorable safety profile for intravenous iron administration, the limitations of the present meta-analysis necessitate continued vigilance regarding potential drug-related risks associated with intravenous iron therapy. Systematic review protocol: CRD420251069827 (PROSPERO).