Does the liver talk to the brain? If so, how and why?

The liver communicates with the brain by transmitting interoceptive signals, including nutrients, hormones, and cytokines, potentially via the liver-innervating vagal sensory neurons. This communication is crucial for maintaining metabolic homeostasis and emotional stability.

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Publication Details

Journal
PLoS Biology
Published
2025-11-13
DOI
https://doi.org/10.1371/journal.pbio.3003491
Primary Topic
Neuroscience of respiration and sleep
Type
article
Field-Weighted Citation Impact
0.00
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article

Does the liver talk to the brain? If so, how and why?

Young‐Hwan Jo
PLoS Biology
Neuroscience of respiration and sleep
article

Does the liver talk to the brain? If so, how and why?

Young‐Hwan Jo
article en

Abstract

The liver communicates with the brain by transmitting interoceptive signals, including nutrients, hormones, and cytokines, potentially via the liver-innervating vagal sensory neurons. This communication is crucial for maintaining metabolic homeostasis and emotional stability.

PLoS BiologyVol. 23(11)
Albert Einstein College of Medicine (US)
Openalex Percentile: Top 65%
Neuroscience of respiration and sleep
DOIOpen Access PDFOpenAlex
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Does the liver talk to the brain? If so, how and why? — Young‐Hwan Jo · PLoS Biology (2025) | TGRS Research Map | TGRS