The Importance of Treatment Timing and Positioning in IBD
This commentary examines the progressive decline in biologic efficacy in inflammatory bowel disease, highlighting pharmacologic, immunologic, and cellular mechanisms of resistance. It advocates for early, biomarker-guided, and mechanistically informed sequencing to preserve long-term therapeutic response and overcome the emerging "therapeutic ceiling."
Authors
- Giulia Valdiserra (ORCID: https://orcid.org/0000-0003-1616-8644)
- Luca Antonioli (ORCID: https://orcid.org/0000-0003-1241-617X)
- Agnese Favale (ORCID: https://orcid.org/0000-0003-4508-4685)
- Massimo Claudio Fantini (ORCID: https://orcid.org/0000-0003-2870-3827)
Institutions
- University of Pisa (IT)
- University of Cagliari (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/ibd/izaf282
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00