Exploring gut microbiota and its predicted functions in pulmonary tuberculosis: A multi-regional study using public 16S datasets
The observed alterations of gut microbial diversity and predicted functional profile underscores the influence of antitubercular therapy on gut health, suggesting that longer treatment durations may aggravate these alterations in gut microbial function. Moreover, geographical location exerts a more significant impact on microbial diversity than the disease state in a specific location, highlighting the potential for precision medicine to tailor interventions based on individual or regional microbiome characteristics.
Authors
- Kavitha Saravu (ORCID: https://orcid.org/0000-0001-6399-1129)
- Tejaswini Baral (ORCID: https://orcid.org/0000-0002-6185-3600)
- Mahadev Rao (ORCID: https://orcid.org/0000-0003-3322-5399)
- Mohan K Manu (ORCID: https://orcid.org/0000-0002-9481-3189)
- Sonal Sekhar Miraj (ORCID: https://orcid.org/0000-0003-3660-2022)
- Anwesh Maile (ORCID: https://orcid.org/0000-0003-2164-3251)
- Chandrashekar Udyavara Kudru (ORCID: https://orcid.org/0000-0002-8274-9677)
- Jitendra Singh (ORCID: https://orcid.org/0000-0001-5626-6076)
- Chiranjay Mukhopadhyay
- Nagarajaram Hampapathalu Adimurthy
Institutions
- Manipal Academy of Higher Education (IN)
- University of Hyderabad (IN)
- All India Institute of Medical Sciences Bhopal (IN)
- Kasturba Medical College, Manipal (IN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1371/journal.pone.0336337
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00