Mineral Particles as Nucleating Agents for Controllable Polymorphic Forms of ROY
The crystallization behavior of the organic molecule 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecarbonitrile (known as ROY for its red, orange, and yellow crystals) was systematically regulated by using various natural mineral particles as heterogeneous nucleating agents. Polarized light microscopy and X-ray diffraction demonstrated that different types of mineral nucleating agents significantly influenced the resulting polymorphic forms of ROY, establishing a clear correlation between the nucleating agent type and the crystal form. Scanning electron microscopy and in situ video microscopy provided detailed insights into the nucleation sites and crystal growth dynamics. Remarkably, these nucleating agents consistently induced specific polymorphs under different crystallization methods and conditions while also modulating the dominant crystal facets. This study highlights the critical role of mineral nucleating agents in manipulating the crystallization process and tailoring the resulting crystal products.
Authors
- Jianglei Zhang (ORCID: https://orcid.org/0009-0009-6696-2273)
- Junhu Zhang (ORCID: https://orcid.org/0000-0001-9100-6608)
- Irshad Hussaın (ORCID: https://orcid.org/0000-0001-5498-1236)
- Chuipeng Kong (ORCID: https://orcid.org/0000-0002-9214-1497)
- Sitang Gong (ORCID: https://orcid.org/0000-0002-6899-0616)
- Gang Chen (ORCID: https://orcid.org/0000-0002-8772-9755)
- Xue-Yuan Guo
- Ning-Ning Zhang (ORCID: https://orcid.org/0000-0002-6308-7399)
- Yang Yang (ORCID: https://orcid.org/0000-0002-0638-4274)
- Kun Liu (ORCID: https://orcid.org/0000-0003-2940-9814)
- Yang Li (ORCID: https://orcid.org/0000-0002-8058-8945)
- Cheng Zheng (ORCID: https://orcid.org/0000-0002-9559-4686)
- Zhenghao Li (ORCID: https://orcid.org/0000-0001-5727-8773)
Institutions
- Jilin University (CN)
- Lahore University of Management Sciences (PK)
- Jilin Jianzhu University (CN)
- Institute of Theoretical Physics (CN)
- Jilin Medical University (CN)
- State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
- State Key Laboratory of Supramolecular Structure and Materials
Publication Details
- Journal
- Crystal Growth & Design
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1021/acs.cgd.5c01206
- Primary Topic
- Crystallization and Solubility Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00