Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions
Troxerutin emerges as a more biocompatible alternative to glucose as an osmotic agent for PD therapy, exhibiting no adverse local or systemic side effects in preclinical studies. This research presents a novel approach to reduce cardiovascular complications of PD in end-stage kidney disease.
Authors
- Etto C. Eringa (ORCID: https://orcid.org/0000-0002-9814-5149)
- Marta Ruiz‐Ortega (ORCID: https://orcid.org/0000-0002-1495-6535)
- Lucía Pascual‐Antón (ORCID: https://orcid.org/0000-0002-7270-1629)
- Antonio Tejera‐Muñoz (ORCID: https://orcid.org/0000-0002-7954-5753)
- Manuel López‐Cabrera (ORCID: https://orcid.org/0000-0002-0976-9719)
- Dorothea Piecha
- Marcelino Cortés (ORCID: https://orcid.org/0000-0002-2304-8547)
- Valeria Kopytina (ORCID: https://orcid.org/0000-0001-7450-0452)
- Marc Vervloet (ORCID: https://orcid.org/0000-0003-4607-9415)
- Juan J. Vaquero (ORCID: https://orcid.org/0000-0002-3820-9673)
- Lisa Strahl
- Nora Toggweiler
- David Sucunza (ORCID: https://orcid.org/0000-0002-3307-4204)
- Guadalupe Tirma Gónzalez-Mateo (ORCID: https://orcid.org/0000-0002-8144-904X)
- Vanessa Marchant (ORCID: https://orcid.org/0000-0002-2767-0229)
- Jamie Kane (ORCID: https://orcid.org/0000-0002-3204-4425)
- Raquel Rodrigues‐Díez (ORCID: https://orcid.org/0000-0002-6348-1505)
Institutions
- Universidad Complutense de Madrid (ES)
- University of Alicante (ES)
- Radboud University Nijmegen (NL)
- Universidad de Alcalá (ES)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Hospital Universitario de Guadalajara (ES)
- Sociedad Española de Medicina de Familia y Comunitaria (ES)
- Amsterdam Neuroscience (NL)
- Instituto Bernabeu (ES)
- Mayo Clinic in Arizona (US)
- Camilo José Cela University (ES)
- Fresenius Medical Care (United States) (US)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Amsterdam University Medical Centers (NL)
- Universidad Autónoma de Madrid (ES)
- University of Amsterdam (NL)
- Fresenius Medical Care (Germany) (DE)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/ndt/gfaf249
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- ZonMw
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund