Subretinal Injection Volume Correlates to Persistent Outer Retinal Thinning in the Pig Eye
This study supports the notion that SRV could be an independent factor in development of outer retinal thinning in the pig eye. Modifying surgical technique to favor the placement of multiple smaller blebs of <100 µL might mitigate retinal thinning because of volumetric stress and enhance the preclinical safety profile of investigational therapies.
Authors
- Daniela Süßkind (ORCID: https://orcid.org/0000-0002-3095-023X)
- Jana Juhásová (ORCID: https://orcid.org/0000-0001-7022-6812)
- Immanuel P. Seitz (ORCID: https://orcid.org/0000-0002-3086-6425)
- Sven Schnichels (ORCID: https://orcid.org/0000-0002-2385-5517)
- Taras Ardan (ORCID: https://orcid.org/0000-0002-4354-8354)
- J. Klein
- Zdeňka Ellederová (ORCID: https://orcid.org/0000-0001-6695-6345)
- Saskia Drutovič (ORCID: https://orcid.org/0000-0002-5103-5073)
- Ashley R. Winslow (ORCID: https://orcid.org/0000-0003-1265-5023)
- Yaroslav Nemesh (ORCID: https://orcid.org/0000-0003-3862-9413)
- Štefan Juhás (ORCID: https://orcid.org/0000-0002-2866-0727)
- Ruslan Nyshchuk (ORCID: https://orcid.org/0000-0002-9838-1547)
- Uwe Wolfrum (ORCID: https://orcid.org/0000-0002-4756-5872)
- Nikolai Klymiuk
- Jan Motlík
- M. Dominik Fischer (ORCID: https://orcid.org/0000-0002-0690-6538)
- Kathryn Post DeMott
Institutions
- Johannes Gutenberg University Mainz (DE)
- Charles University (CZ)
- TUM Klinikum (DE)
- University of Oxford (GB)
- Quantitative BioSciences (US)
- Czech Academy of Sciences, Institute of Animal Physiology and Genetics (CZ)
- University Children's Hospital Tübingen (DE)
- STZ eyetrial (DE)
- Oxford University Hospitals NHS Trust (GB)
- Technical University of Munich (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1167/iovs.66.14.27
- Citations
- 1
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Biogen
- Deutsche Forschungsgemeinschaft
- Akademie Věd České Republiky
- Astellas Pharma