Measurement Reliability and Functional Validity of Bruch's Membrane Calcification in Pseudoxanthoma Elasticum: PROPXE Study Report 2
Patients with PXE demonstrate significant rod-mediated dark adaptation deficits correlating with the temporal inner peau d'orange boundary extent. These findings support the use of BrM calcification extent as an objective marker for disease severity, facilitating earlier therapeutic intervention than currently possible in PXE.
Authors
- Maximilian Pfau (ORCID: https://orcid.org/0000-0001-9761-9640)
- Georg Ansari (ORCID: https://orcid.org/0009-0008-4693-2061)
- Sharon F. Terry (ORCID: https://orcid.org/0000-0002-0452-9329)
- Kristina Pfau (ORCID: https://orcid.org/0000-0002-3642-3502)
- Peter Charbel Issa (ORCID: https://orcid.org/0000-0002-0351-6673)
- Jason A. W. Giger
Institutions
- Twitter (United States) (US)
- University of Bonn (DE)
- University of Basel (CH)
- ORCID (US)
- Technical University of Munich (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1167/iovs.66.14.29
- Primary Topic
- Dermatological and Skeletal Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00