Haemodynamic determinants of supine hypertension in patients with classical orthostatic hypotension
While high supine TPR explained SH, a failure to further increase upright TPR explained the orthostatic SBP fall in patients. Autonomic failure can explain the SBP fall but not directly the high supine TPR that causes SH. We assume that slow-acting humoral vasoconstrictors are triggered in the upright position and continue to act after tilting back, causing high TPR and SH.
Authors
- Ineke A. van Rossum (ORCID: https://orcid.org/0000-0002-0999-7156)
- Roland D. Thijs (ORCID: https://orcid.org/0000-0003-1435-8970)
- Gert van Dijk (ORCID: https://orcid.org/0000-0001-8916-6231)
- Marc J. van Houwelingen (ORCID: https://orcid.org/0009-0002-1885-5835)
- Sharon Shmuely (ORCID: https://orcid.org/0000-0001-9413-6125)
- Robert Reijntjes (ORCID: https://orcid.org/0000-0002-7784-1807)
- Fabian I. Kerkhof (ORCID: https://orcid.org/0000-0002-8588-3273)
- Boriana S. Gagaouzova (ORCID: https://orcid.org/0000-0002-3219-1548)
- Amber H. van der Stam
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Stichting Epilepsie Instellingen Nederland (NL)
- University College London (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1097/hjh.0000000000004194
- Primary Topic
- Cardiovascular Syncope and Autonomic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00