Rotasiil vaccine effectiveness against rotavirus-associated hospitalizations in the Democratic Republic of the Congo: comparison of multivariate logistic regression and inverse probability treatment weighting methods in a test-negative design

Rotasiil vaccination under conditions of routine use effectively reduces rotavirus-associated diarrhea hospitalizations among children, supporting the ongoing use of rotavirus vaccine. The IPTW VE estimate was more precise than multivariate logistic regression but the confidence intervals overlapped, suggesting that the resulting VE estimates are not statistically different and the methods are complementary.

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Publication Details

Journal
Vaccine
Published
2025-11-11
DOI
https://doi.org/10.1016/j.vaccine.2025.127944
Citations
1
Primary Topic
Viral gastroenteritis research and epidemiology
Type
article
Field-Weighted Citation Impact
1.40
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article

Rotasiil vaccine effectiveness against rotavirus-associated hospitalizations in the Democratic Republic of the Congo: comparison of multivariate logistic regression and inverse probability treatment weighting methods in a test-negative design

Pablito Nasaka, Étienne Volatier, Audry Mulumba, Eleanor Burnett et al.
1 citations
Vaccine
Viral gastroenteritis research and epidemiology
1.40
article

Rotasiil vaccine effectiveness against rotavirus-associated hospitalizations in the Democratic Republic of the Congo: comparison of multivariate logistic regression and inverse probability treatment weighting methods in a test-negative design

Pablito Nasaka, Étienne Volatier, Audry Mulumba, Eleanor Burnett, Odile Launay, Elisabeth Pukuta, Umesh D. Parashar, John Ditekemena, John Samuel Otomba, Jacqueline E. Tate, Christophe Luhata Lungayo, Romain Jouffroy, Rachel M. Burke, Alpha Oumar Diallo, Raymond Adhaku, Marie‐Aliette Dommergues, Jason M. Mwenda, Noela Mosala, Dominique Muteba, Medard Ngoy, Dido Disengomoka Domingo, Francis Ngoy, Augustin Milabyo
article en
1 citations

Abstract

Rotasiil vaccination under conditions of routine use effectively reduces rotavirus-associated diarrhea hospitalizations among children, supporting the ongoing use of rotavirus vaccine. The IPTW VE estimate was more precise than multivariate logistic regression but the confidence intervals overlapped, suggesting that the resulting VE estimates are not statistically different and the methods are complementary.

VaccineVol. 68
Centers for Disease Control and Prevention (US), Ministry of Public Health (CD), Gavi (CH), Inserm (FR), Université Paris Cité (FR), Université Paris-Saclay (FR), Sefako Makgatho Health Sciences University (ZA), Kinshasa General Hospital (CD), University of Kinshasa (CD), Centre de recherche en Epidémiologie et Santé des Populations (FR), Ministère De La Santé (BF), National Institute of Biomedical Research (CD), Institut Cochin (FR), Centre Hospitalier de Versailles (FR)
Openalex Percentile: Top 14%
Viral gastroenteritis research and epidemiology
1.40
DOIOpen Access PDFOpenAlex
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