Plasma metabolic profiling identifies elevated hippurate as a potential biomarker of methotrexate non-response in juvenile idiopathic arthritis
These findings support plasma metabolomic differences associated with the response to MTX in JIA. The identification of hippurate, indoles, and other gut microbial-derived metabolites continues to draw attention to the potential relationship between the gut microbiome and MTX treatment response in JIA.
Authors
- Ryan S. Funk (ORCID: https://orcid.org/0000-0002-3834-4672)
- Mara L. Becker (ORCID: https://orcid.org/0009-0008-1088-2015)
- Amar Kumar (ORCID: https://orcid.org/0000-0001-8513-673X)
Institutions
- University of Kansas (US)
- Illinois College (US)
- Duke University (US)
- The University of Kansas Health System (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.biopha.2025.118755
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77