Genomic and Immune Correlates of <scp>EZH2</scp> Expression and Activity in Olfactory Neuroblastoma
Taken together, our data suggest that low EZH2 activity is associated with a more immunogenic microenvironment, paving the way for potential combinations of EZH2 inhibitors with checkpoint blockade in ONB.
Authors
- Tolulope Adeyelu (ORCID: https://orcid.org/0000-0003-0615-0731)
- Dara Bracken‐Clarke (ORCID: https://orcid.org/0000-0002-1105-1079)
- Andrew Elliott (ORCID: https://orcid.org/0000-0001-8494-8031)
- Harris B. Krause (ORCID: https://orcid.org/0000-0003-3481-8364)
- Ari M. Vanderwalde (ORCID: https://orcid.org/0000-0002-6842-2563)
- Ranee Mehra (ORCID: https://orcid.org/0000-0003-2477-9584)
- Nyall R. London (ORCID: https://orcid.org/0000-0002-2902-4407)
- Charalampos S. Floudas (ORCID: https://orcid.org/0000-0002-0020-237X)
- Heloisa P. Soares (ORCID: https://orcid.org/0000-0002-5185-2583)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Elisabetta Xue (ORCID: https://orcid.org/0000-0002-1963-9555)
- David B. Spetzler (ORCID: https://orcid.org/0000-0002-9531-0970)
- James L. Gulley
Institutions
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- Huntsman Cancer Institute (US)
- University of Minnesota Medical Center (US)
- Caris Life Sciences (United States) (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/hed.70076
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute